Kennedy M J, Phillips F E
Animal Health Laboratories Branch, Alberta Agriculture, Edmonton, Canada.
Vet Parasitol. 1993 Jul;49(1):61-6. doi: 10.1016/0304-4017(93)90224-b.
The anthelmintic efficacy of doramectin was assessed for the control of Thelazia spp. in two studies using 44 naturally or experimentally infected calves. Cattle were randomly assigned based on weight to either a doramectin treatment group or a saline control group. Treated animals received doramectin at a dosage of 200 micrograms kg-1, subcutaneously in the lateral midline of the neck. Control animals received an equivalent dosage of 0.9% sterile saline. Animals were slaughtered 13-16 days after treatment and all eyes and associated tissues (including the lacrymal glands and ducts) were removed and examined for total number, species and viability of eyeworms. Two species of eyeworms, Thelazia skrjabini and Thelazia gulosa were found in the control group of naturally infected calves. Only T. skrjabini was found in the control group of experimentally infected calves. No eyeworms were found in any doramectin-treated animal. The efficacy of doramectin against Thelazia spp. in both naturally and experimentally infected calves was 100%.
在两项研究中，使用44头自然感染或实验感染的犊牛评估了多拉菌素对控制吸吮线虫属的驱虫效果。根据体重将牛随机分为多拉菌素治疗组或生理盐水对照组。治疗动物在颈部外侧中线皮下注射200微克/千克剂量的多拉菌素。对照动物接受等量的0.9%无菌生理盐水。治疗后13 - 16天宰杀动物，摘除所有眼睛及相关组织（包括泪腺和泪管），检查眼虫的总数、种类和活力。在自然感染犊牛的对照组中发现了两种眼虫，即斯氏吸吮线虫和大口吸吮线虫。在实验感染犊牛的对照组中仅发现了斯氏吸吮线虫。在任何接受多拉菌素治疗的动物中均未发现眼虫。多拉菌素对自然感染和实验感染犊牛体内吸吮线虫属的驱虫效果均为100%。
