Sochanowicz B, Dancewicz A M
Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warszawa, Poland.
Acta Biochim Pol. 1992;39(3):271-81.
The irradiation of whole body of rabbits with a dose of 6.0 Gy causes an increase in thromboxane synthesis from exogenous arachidonic acid. The uptake of [14C]arachidonic acid and the total amount of radioactivity released during collagen stimulated aggregation of platelets are not changed following the exposure of animals. The irradiation changes the relation between released arachidonic acid and synthesized thromboxane. The amount of 12-hydroxyeicosatetraenoic acid remains unchanged. The results indicate that the increase in thromboxane synthesis is not associated with the activation of phospholipase but is caused by stimulation of cyclooxygenase activity.
以6.0 Gy的剂量对兔全身进行照射，会导致外源性花生四烯酸的血栓素合成增加。在动物暴露后，[14C]花生四烯酸的摄取以及胶原刺激血小板聚集过程中释放的放射性总量并未改变。照射改变了释放的花生四烯酸与合成的血栓素之间的关系。12-羟基二十碳四烯酸的量保持不变。结果表明，血栓素合成的增加与磷脂酶的激活无关，而是由环氧化酶活性的刺激引起的。
