Rzymowska J
Department of Cell Biology, University of Maria Curie-Skłodowska, Lublin, Poland.
Acta Biochim Pol. 1992;39(3):289-94.
The activities of six enzymes associated with carbohydrate metabolism were measured both in carcinomas and in normal breast tissues. The following differences were observed. 1. The carcinoma showed higher enzyme activities than the normal mammary tissue. 2. The ratios of glutamate dehydrogenase, hydroxybutyrate dehydrogenase, glutathione reductase and catalase to lactate dehydrogenase were lower in carcinomas than in normal tissues. Similarly, the ratios of glutamate dehydrogenase, hydroxybutyrate dehydrogenase, glutathione reductase and catalase to glucose-6-phosphate dehydrogenase were also significantly lower in carcinomas. 3. There were no significant differences in enzyme activities between I and II stage of the disease and the metastatic tissues, however, there were significant differences between I and III stage. The significance of these findings is discussed in terms of the alterations in the balance between the metabolic pathways.
在癌组织和正常乳腺组织中均测定了与碳水化合物代谢相关的六种酶的活性。观察到以下差异：1. 癌组织中的酶活性高于正常乳腺组织。2. 癌组织中谷氨酸脱氢酶、羟丁酸脱氢酶、谷胱甘肽还原酶和过氧化氢酶与乳酸脱氢酶的比值低于正常组织。同样，癌组织中谷氨酸脱氢酶、羟丁酸脱氢酶、谷胱甘肽还原酶和过氧化氢酶与葡萄糖-6-磷酸脱氢酶的比值也显著较低。3. 疾病的I期和II期与转移组织之间的酶活性无显著差异，但I期和III期之间存在显著差异。根据代谢途径之间平衡的改变对这些发现的意义进行了讨论。
