Cisteró A, Urías S, Guindo J, Lleonart R, Garcia-Moll M, Geli A, Bayés de Luna A
Allergy Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Allergy. 1992 Oct;47(5):576-8. doi: 10.1111/j.1398-9995.1992.tb00686.x.
We present the case of a 43-year-old man who suffered an acute myocardial infarction after oral administration of 250 mg of naproxen, prescribed as antiinflammatory-analgesic agent after tooth extraction. Both intradermal skin test and human basophil degranulation test were positive to naproxen. These findings suggest a naproxen-associated anaphylactic reaction with concomitant coronary artery spasm and posteroinferior infarction, a clinical event previously not reported with the use of this drug.
我们报告一例43岁男性病例，该患者在口服250毫克萘普生后发生急性心肌梗死，萘普生是拔牙后作为抗炎镇痛药开具的。皮内皮肤试验和人嗜碱性粒细胞脱颗粒试验对萘普生均呈阳性。这些发现提示萘普生相关的过敏反应伴有冠状动脉痉挛和后下壁梗死，这是此前使用该药物时未报告过的临床事件。
