Apaydin C, Gur B, Yakupoglu G, Saka O
Department of Ophthalmology, Akdeniz University, Antalya, Turkey.
Ann Ophthalmol. 1992 Dec;24(12):465-9.
In this study, we investigated the ocular and visual side effects of systemic cyclosporine used as an immunosuppressant in 51 renal transplant recipients during the postoperative period. Three different treatment schemes were used. The patients in the first group received cyclosporine and a corticosteroid. The second group was given azathioprine and a corticosteroid. Those in the third group were treated with azathioprine, a corticosteroid, and cyclosporine. Cotton-wool exudates, retinal hemorrhages, and retinal artery branch occlusion were observed only in one patient each in the second group, and these patients were excluded from the statistical evaluation. Macular hyperpigmentation was observed as a new finding in each group, but there was no statistical difference between the groups. The same results were found for cataract; this probably was related to the use of steroids. Trichomegaly, visual hallucinations, and cerebral blindness were not observed by contrast with previous studies. We suggest that systemic cyclosporine does not have significant ocular and visual side effects.
在本研究中，我们调查了51例肾移植受者术后使用全身性环孢素作为免疫抑制剂时的眼部和视觉副作用。采用了三种不同的治疗方案。第一组患者接受环孢素和一种皮质类固醇。第二组给予硫唑嘌呤和一种皮质类固醇。第三组患者接受硫唑嘌呤、一种皮质类固醇和环孢素治疗。仅在第二组的一名患者中观察到棉絮状渗出物、视网膜出血和视网膜动脉分支阻塞，这些患者被排除在统计评估之外。在每组中均观察到黄斑色素沉着这一新发现，但各组之间无统计学差异。白内障也得到了相同的结果；这可能与类固醇的使用有关。与先前的研究相比，未观察到睫毛粗长、视幻觉和皮质盲。我们认为全身性环孢素没有明显的眼部和视觉副作用。
