Paneau C, Schaffer P, Bollack C
Laboratoire d'Epidémiologie et de Santé Publique, Faculté de Médecine, Strasbourg.
Ann Urol (Paris). 1992;26(5):281-93.
The urinary bladder cancer mortality varies in different countries. The highest rates are noted in Denmark, UK, Belgium and Italy, the lowest rates in Japan, Singapore and Venezuela. The mortality rates are increasing for both males and females. In France, the highest rates are observed in the South of France contrary to other cancer sites. The highest incidence rates are observed in Europe, in USA and in some countries of Africa. In these same areas, the rates are higher for males and are increasing with time. The mortality is high in the first years after diagnosis. The five-year relative survival rates are 41%, for males and 35% for females. Tobacco, and especially cigarettes, is a well known risk factor. A dose effect relation appears to exist. The occupational risk factors are potentiated by tobacco and modifications are noted and are in relation with new factors. Ground coffee is associated with urinary bladder cancer and appears to be a co-carcinogenic factor with tobacco. Some drugs, such as antimitotics, phenacetin, radiation and urinary bilharziosis, are etiological factors of this cancer. The role of artificial sweeteners, alcohol and nutrition is less well documented.
膀胱癌死亡率在不同国家有所不同。丹麦、英国、比利时和意大利的死亡率最高,日本、新加坡和委内瑞拉的死亡率最低。男性和女性的死亡率都在上升。在法国,与其他癌症发病部位不同,法国南部的死亡率最高。欧洲、美国和非洲的一些国家发病率最高。在这些相同地区,男性发病率更高且随时间增加。诊断后的头几年死亡率很高。男性五年相对生存率为41%,女性为35%。烟草,尤其是香烟,是众所周知的风险因素。似乎存在剂量效应关系。职业风险因素因烟草而增强,并且有变化,且与新因素有关。研磨咖啡与膀胱癌有关,似乎是与烟草共同致癌的因素。一些药物,如抗有丝分裂药、非那西丁、辐射和泌尿血吸虫病,是这种癌症的病因。人工甜味剂、酒精和营养的作用记录较少。