静脉注射用免疫球蛋白制剂中IgG亚类的分布
IgG subclasses distribution in immunoglobulin preparations for intravenous use.
作者信息
Bozadjiev L G, Bineva I L, Vassilev T L
机构信息
Institute of Infectious and Parasitic Diseases, Sofia, Bulgaria.
出版信息
Arch Immunol Ther Exp (Warsz). 1992;40(1):79-81.
PMID:1485832
Abstract
The levels of IgG subclasses were determined, by radial immunodiffusion using monoclonal antibodies, in 16 production batches of two human immunoglobulin preparations for intravenous use--Immunovenin and Immunovenin-intact. While the partially degraded preparation--Immunovenin contained exclusively IgG1, the subclass distribution in Immunovenin-intact was close to that observed in normal human serum.
摘要
使用单克隆抗体通过放射免疫扩散法测定了两种静脉用人免疫球蛋白制剂——免疫静脉注射剂和完整免疫静脉注射剂的16个生产批次中的IgG亚类水平。部分降解的制剂——免疫静脉注射剂仅含有IgG1，而完整免疫静脉注射剂中的亚类分布与正常人血清中观察到的情况相近。
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