GINSBERG H S
J Exp Med. 1951 Sep;94(3):191-211. doi: 10.1084/jem.94.3.191.
Infectious NDV particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. The lesions are indistinguishable from those of influenza A virus infection. This effect of NDV was blocked by intranasal injection of RDE or immune serum before virus inoculation, but not by immune serum injected 5 minutes or more after NDV. Influenza A virus infection did not diminish fixation of NDV in excised lungs but did interfere with the injurious action of this agent in the living mouse. The analogy between these reactions and those which take place in a progressive virus infection is pointed out, and the mechanism of production of lesions in virus pneumonias discussed.
在没有可证明的病毒增殖情况下,传染性新城疫病毒(NDV)颗粒在小鼠体内可导致广泛的肺部实变。这些病变与甲型流感病毒感染所致病变无法区分。在接种病毒前经鼻内注射抗血清(RDE)或免疫血清可阻断NDV的这种作用,但在接种NDV 5分钟或更长时间后注射免疫血清则不能阻断。甲型流感病毒感染不会减少NDV在离体肺中的固定,但确实会干扰该病原体在活体小鼠中的损伤作用。文中指出了这些反应与进行性病毒感染中发生的反应之间的相似性,并讨论了病毒性肺炎中病变产生的机制。