Brolin J, Löwhagen T, Skoog L
Department of Urology, Karolinska Hospital, Stockholm, Sweden.
Cytopathology. 1992;3(6):351-7. doi: 10.1111/j.1365-2303.1992.tb00060.x.
A monoclonal antibody to the androgen receptor was applied to fine needle aspirates from patients with benign and malignant prostatic disease. The series includes six patients with benign hyperplasia and 24 patients with prostatic carcinomas. The androgen receptor was detected in most nuclei of both benign and malignant epithelial cells. The intensity of immunostaining varied. No obvious relation was observed between the intensity of the staining in benign versus malignant cells. In addition no clear differences were found in the proportion of androgen receptor positive cells in benign aspirates as compared with aspirates from well differentiated or moderately well differentiated prostatic carcinomas. The relative number of androgen receptor positive cells was highest in smears from poorly differentiated prostatic carcinomas.
一种抗雄激素受体的单克隆抗体被应用于患有良性和恶性前列腺疾病患者的细针穿刺抽吸物。该系列包括6例良性增生患者和24例前列腺癌患者。在良性和恶性上皮细胞的大多数细胞核中均检测到雄激素受体。免疫染色强度各不相同。未观察到良性细胞与恶性细胞染色强度之间存在明显关系。此外，与高分化或中分化前列腺癌的抽吸物相比，良性抽吸物中雄激素受体阳性细胞的比例未发现明显差异。在低分化前列腺癌涂片样本中，雄激素受体阳性细胞的相对数量最高。
