Alexander G J, Kopeloff L M
Pharmacol Biochem Behav. 1978 Mar;8(3):291-3. doi: 10.1016/0091-3057(78)90319-2.
We have reported previously that para-chlorophenylalanine prevented seizure manifestations in an inbred strain of mice genetically predisposed to audiogenic seizures. We now find that this protective effect is not limited to a particular inbred strain of susceptible animals but can be demonstrated in Swiss-Webster and CF No.1 strains which were not originally subject to audiogenic seizures but in which we have induced audiosusceptibility through maintenance on a low magnesium diet.
我们之前曾报道过，对氯苯丙氨酸可预防一种遗传性易患听源性癫痫的近交系小鼠出现癫痫发作表现。我们现在发现，这种保护作用并不局限于特定的易患癫痫的近交系动物，在瑞士韦伯斯特小鼠和CF 1号小鼠中也能观察到，这两种小鼠原本不会出现听源性癫痫发作，但我们通过用低镁饮食饲养诱导了它们的听源性易感性。
