Anticonvulsive effect of p-chlorophenylalanine in mice on a low magnesium diet.

We have reported previously that para-chlorophenylalanine prevented seizure manifestations in an inbred strain of mice genetically predisposed to audiogenic seizures. We now find that this protective effect is not limited to a particular inbred strain of susceptible animals but can be demonstrated in Swiss-Webster and CF No.1 strains which were not originally subject to audiogenic seizures but in which we have induced audiosusceptibility through maintenance on a low magnesium diet.