Bac P, Pages N, Dhalluin S, Tapiero H
Department of Cellular and Molecular Pharmacology, CNRS URA 1218, Université de Paris--Faculté de Pharmacie, Châtenay-Malabry, France.
Biomed Pharmacother. 1998;52(4):162-5. doi: 10.1016/s0753-3322(98)80205-9.
Audiogenic seizures associated with loss of weight, prostration, piloerection, palpebral ptosis and motor deficiency were induced after sound stimulation of determined frequency and amplitude in magnesium-deficient DBA/2 mice. These symptoms were maintained when standard diet conditions (1700 ppm Mg2+) were restored. In contrast, mice were protected from audiogenic seizure in a dose related manner when Crassostrea gigas extract (JCOE) were added to the diet for 10 consecutive days. Although a rational explanation for this protective effect has not yet been determined, it is assumed that it might be due to a chelating complex formed between Mg2+ and taurine, which enhance the uptake of Mg2+.
在对缺镁的DBA/2小鼠进行特定频率和振幅的声音刺激后，诱发了与体重减轻、虚脱、竖毛、睑下垂和运动功能缺陷相关的听源性癫痫发作。当恢复标准饮食条件（1700 ppm Mg2+）时，这些症状仍持续存在。相比之下，当连续10天在饮食中添加太平洋牡蛎提取物（JCOE）时，小鼠以剂量相关的方式免受听源性癫痫发作的影响。尽管尚未确定这种保护作用的合理解释，但推测可能是由于Mg2+与牛磺酸之间形成了螯合复合物，从而增强了Mg2+的吸收。
