Buck D R, Mahoney A W, Hendricks D G
Pharmacol Biochem Behav. 1976 Nov;5(5):529-34. doi: 10.1016/0091-3057(76)90264-1.
Magnesium deficiency in weanling rats caused an increase in NEL and in audiogenic seizure susceptibility. These behavioral effects were apparent after eight days of magnesium restriction and could be reversed by dietary rehabilitation. Serum magnesium declined rapidly from 1.87 +/- 0.10 mEq/L to 0.91 +/- 0.24 mEq/L in two days. Cerebrospinal fluid (CSF) magnesium decreased gradually from 1.86 mEq/L, becoming significantly lower (1.44 +/- 0.23 mEq/L) after eight days. When deficient rats were injected IP with MgCl2, raising the serum magnesium concentration to 6.6 mEq/L, NEL decreased to normal while audiogenic seizure susceptibility remained. Both NEL and audiogenic seizure susceptibility in rats reflect central nervous system magnesium concentration, except when serum magnesium concentration is very high. Very high serum magnesium concentration lowers NEL but does not reduce audiogenic seizure susceptibility if CSF magnesium is low.
断奶大鼠缺镁会导致负增强作用（NEL）增加以及对听源性癫痫发作的易感性增加。在限制镁摄入八天后，这些行为效应变得明显，并且可以通过饮食恢复正常。血清镁在两天内从1.87±0.10毫当量/升迅速降至0.91±0.24毫当量/升。脑脊液（CSF）镁从1.86毫当量/升逐渐下降，八天后显著降低（1.44±0.23毫当量/升）。当向缺镁大鼠腹腔注射氯化镁，使血清镁浓度升至6.6毫当量/升时，负增强作用降至正常水平，但对听源性癫痫发作的易感性仍然存在。大鼠的负增强作用和对听源性癫痫发作的易感性均反映中枢神经系统镁浓度，血清镁浓度非常高时除外。血清镁浓度非常高会降低负增强作用，但如果脑脊液镁含量低，则不会降低对听源性癫痫发作的易感性。
