Compston J E, Bhambhani M, Laskey M A, Murphy S, Khaw K T
Department of Medicine, University of Cambridge Clinical School, UK.
Clin Endocrinol (Oxf). 1992 Nov;37(5):426-31. doi: 10.1111/j.1365-2265.1992.tb02354.x.
We aimed to assess total body composition and to study the interrelationships between fat and lean tissue mass with total and regional bone mass in healthy British post-menopausal women.
Total body composition and regional bone mass were measured in 97 healthy post-menopausal women recruited from the general community. The mean age was 57.9 years, range 49-65.
Total body composition (fat, lean tissue and bone mineral) and regional bone density in the lumbar spine and femur were measured by dual energy X-ray absorptiometry on a Lunar DPX.
Significant negative correlations with age were found for total body bone mineral density (r = -0.200, P = 0.049), and lumbar spine bone mineral density (r = -0.28, P = 0.006); the calculated rate of bone loss from these two sites was 0.33 and 0.7% per annum respectively. Fat tissue mass showed a positive correlation with age (r = 0.22, P = 0.03). High correlations were observed between total body and regional bone mineral density (r = 0.755-0.829, P < 0.001). After adjustment for age and lean mass, statistically significant correlations were seen between fat tissue mass and all bone mass measurements (P < 0.01-0.001), the strongest correlations being found for total body bone mineral content and density (r = 0.477 and 0.488 respectively). Lean tissue mass showed a strong correlation with total body bone mineral content (r = 0.580, P < 0.001), after adjustment for age and fat mass; it was less strongly correlated with other bone mass measurements than fat mass, showing only weak correlations with total body, trochanteric and lumbar spine bone mineral density (r = 0.228-0.246, P < 0.05). Age-adjusted body weight showed stronger correlations with total and regional bone mass than did either body mass index or height.
Both fat and lean tissue mass are related to total and regional bone mass in post-menopausal women, the relationship being strongest for fat mass. Body weight shows stronger correlations with bone mass than either height or body mass index. In view of the direction and magnitude of changes in fat, lean tissue and bone mineral after the menopause, adiposity and muscularity are more likely to be determinants of peak bone mass than of the rate of post-menopausal bone loss.
我们旨在评估健康英国绝经后女性的全身成分，并研究脂肪和瘦组织质量与全身及局部骨量之间的相互关系。
对从普通人群中招募的97名健康绝经后女性进行了全身成分和局部骨量测量。平均年龄为57.9岁，范围在49 - 65岁之间。
使用Lunar DPX双能X线吸收法测量全身成分（脂肪、瘦组织和骨矿物质）以及腰椎和股骨的局部骨密度。
全身骨矿物质密度（r = -0.200，P = 0.049）和腰椎骨矿物质密度（r = -0.28，P = 0.006）与年龄呈显著负相关；这两个部位的计算骨丢失率分别为每年0.33%和0.7%。脂肪组织质量与年龄呈正相关（r = 0.22，P = 0.03）。全身和局部骨矿物质密度之间观察到高度相关性（r = 0.755 - 0.829，P < 0.001）。在调整年龄和瘦体重后，脂肪组织质量与所有骨量测量值之间存在统计学显著相关性（P < 0.01 - 0.001），全身骨矿物质含量和密度的相关性最强（分别为r = 0.477和0.488）。在调整年龄和脂肪质量后，瘦组织质量与全身骨矿物质含量呈强相关（r = 0.580，P < 0.001）；与其他骨量测量值的相关性不如脂肪质量强，与全身、转子和腰椎骨矿物质密度仅呈弱相关（r = 0.228 - 0.246，P < 0.05）。调整年龄后的体重与全身和局部骨量的相关性比体重指数或身高更强。
脂肪和瘦组织质量均与绝经后女性的全身及局部骨量相关，其中脂肪质量的关系最为密切。体重与骨量的相关性比身高或体重指数更强。鉴于绝经后脂肪、瘦组织和骨矿物质变化的方向和幅度，肥胖和肌肉量更可能是峰值骨量的决定因素，而非绝经后骨丢失率的决定因素。
