Archer M C, Bruce W R, Chan C C, Corpet D E, Medline A, Roncucci L, Stamp D, Zhang X M
Ontario Cancer Institute, Toronto, Canada.
Environ Health Perspect. 1992 Nov;98:195-7. doi: 10.1289/ehp.9298195.
Foci of aberrant crypts similar to those seen in experimental animals exposed to colon carcinogens have been identified and quantified on the mucosal surface of fixed resections of human colon after methylene blue staining. Many of the foci in humans showed dysplasia on histologic examination and were considered to be microadenoma (MA). These lesions may be precursors for adenomatous polyps and colorectal cancer. Rats and mice initiated with azoxymethane, then fed diets containing sucrose or casein heated at 180 degrees C to stimulate normal cooking conditions, had three to five times more large MA after 100 days than controls. Thus, cooked sugar and protein contain promoters of the growth of colonic MA. 5-Hydroxymethylfuraldehyde was identified as a promoter in cooked sugar.
在亚甲蓝染色后，已在人类结肠固定切除标本的黏膜表面识别并量化了与暴露于结肠致癌物的实验动物中所见类似的异常隐窝病灶。在组织学检查中，许多人类病灶显示发育异常，被认为是微腺瘤（MA）。这些病变可能是腺瘤性息肉和结直肠癌的前体。用氧化偶氮甲烷启动的大鼠和小鼠，然后喂食含有在180摄氏度加热以模拟正常烹饪条件的蔗糖或酪蛋白的饮食，100天后，大型MA的数量比对照组多三到五倍。因此，熟糖和蛋白质含有结肠MA生长的促进剂。5-羟甲基糠醛被确定为熟糖中的一种促进剂。
