Vostrikov V M, Uranova N A, Rakhmanova V I, Orlovskaia D D
Zh Nevrol Psikhiatr Im S S Korsakova. 2004;104(1):47-51.
Using optical dissector methodology, a morphometric study of numerical density of oligodendroglial cells in layer VI and in adjacent white matter of Broadmann area 10 has been conducted in 23 postmortem brains of schizophrenics and 20 matched controls. Comparing to controls, a significant reduction of numerical density of oligodendroglial cells was found in layer VI (by 31%) and adjacent white matter (by 12%) of schizophrenic patients. The data obtained, as well as ultrastructural signs of oligodendroglial cells apoptosis and necrosis found earlier by the authors, may indicate a loss of these cells in the prefrontal cortex in schizophrenia, which may, in its turn, result in neuronal and high cortical dysfunctions.
利用光学分割器方法，对23例精神分裂症患者的尸检大脑和20例匹配的对照者进行了布罗德曼10区第VI层和相邻白质中少突胶质细胞数量密度的形态计量学研究。与对照组相比，精神分裂症患者第VI层（减少31%）和相邻白质（减少12%）中的少突胶质细胞数量密度显著降低。所获得的数据，以及作者先前发现的少突胶质细胞凋亡和坏死的超微结构迹象，可能表明精神分裂症患者前额叶皮质中这些细胞的丧失，这反过来可能导致神经元和高级皮质功能障碍。
