Uranova N A, Orlovskaia D D, Vikhreva O V, Zimina I S, Rakhmanova V I
Vestn Ross Akad Med Nauk. 2001(7):42-8.
A qualitative and quantitative electron microscopic study of oligodendroglial cells was performed in autoptic (4-6.5 hours after death) prefrontal area 10 in 16 cases of schizophrenia, 6 cases of bipolar affective disorder and 16 normal controls, as well as in the caudate nucleus in same schizophrenic and control cases. The signs of reactive, regressive, and progressive changes of oligodendroglia were described in endogenous psychoses. ANOVA demonstrated a significant decrease in the area of the nucleus, in the volume density of euchromatin, in the volume density and count of mitochondria in oligodendroglial cells in the caudate nucleus and prefrontal area. In affective psychosis, there was a significant reduction in the area of the nucleus and in the volume density of euchromatin and slight changes in cellular organelles. No correlation between the changes and the postmortem interval, age, and neuroleptic therapy, as well as the most pronounced changes in oligodendroglial cells in subgroups of continuous schizophrenia and those with predominantly negative symptoms suggest the involvement of abnormal oligodendroglial cells in the pathogenesis of endogenous psychoses.
对16例精神分裂症患者、6例双相情感障碍患者及16名正常对照者死后4 - 6.5小时的前额叶10区进行了少突胶质细胞的定性和定量电子显微镜研究，同时也对相同精神分裂症患者和对照者的尾状核进行了研究。描述了内源性精神病中少突胶质细胞反应性、退行性和进行性变化的特征。方差分析表明，尾状核和前额叶区域少突胶质细胞核面积、常染色质体积密度、线粒体体积密度和数量均显著减少。在情感性精神病中，细胞核面积和常染色质体积密度显著降低，细胞器有轻微变化。这些变化与死后间隔时间、年龄、抗精神病药物治疗之间无相关性，以及持续性精神分裂症亚组和以阴性症状为主的患者中少突胶质细胞最明显的变化表明，异常少突胶质细胞参与了内源性精神病的发病机制。
