Lehmann Fredrik, Pilotti Ake, Luthman Kristina
Department of Chemistry--Medicinal Chemistry, Göteborg University, Göteborg, Sweden.
Mol Divers. 2003;7(2-4):145-52. doi: 10.1023/b:modi.0000006809.48284.ed.
A series of substituted acetophenones, paraformaldehyde, and symmetrical dialkylamines were used in microwave enhanced Mannich reactions. Appropriate reaction conditions in terms of choice of solvent, reaction temperature, and reaction time were studied to allow a fast and reproducible production of Mannich bases. Both small (2 mmol) and large scale reactions (40 mmol) were performed successfully, providing a series of substituted Mannich bases in moderate to high yields and high purity.
一系列取代苯乙酮、多聚甲醛和对称二烷基胺用于微波增强的曼尼希反应。研究了在溶剂选择、反应温度和反应时间方面的合适反应条件，以实现曼尼希碱的快速且可重复生产。成功进行了小规模（2 mmol）和大规模反应（40 mmol），以中等到高的产率和高纯度提供了一系列取代曼尼希碱。
