Tu Shujiang, Jiang Bo, Zhang Yan, Jia Runhong, Zhang Junyong, Yao Changsheng, Shi Feng
Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant Xuzhou, Jiangsu, 211116, P R China.
Org Biomol Chem. 2007 Jan 21;5(2):355-9. doi: 10.1039/b614747j. Epub 2006 Dec 4.
A facile and selective synthesis of N-substituted 2-aminopyridines is accomplished via microwave-assisted multi-component reactions controlled by the basicity of amine and the nature of solvent. In addition, a possible mechanism accounting for the reaction was proposed.
通过微波辅助多组分反应，利用胺的碱性和溶剂的性质进行控制，实现了N-取代2-氨基吡啶的简便、选择性合成。此外，还提出了一种可能的反应机理。
