通过微波辅助多组分反应高效、化学选择性合成N-取代的2-氨基吡啶。
An efficient and chemoselective synthesis of N-substituted 2-aminopyridines via a microwave-assisted multicomponent reaction.
作者信息
Tu Shujiang, Jiang Bo, Zhang Yan, Jia Runhong, Zhang Junyong, Yao Changsheng, Shi Feng
机构信息
Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant Xuzhou, Jiangsu, 211116, P R China.
出版信息
Org Biomol Chem. 2007 Jan 21;5(2):355-9. doi: 10.1039/b614747j. Epub 2006 Dec 4.
DOI:10.1039/b614747j
PMID:17205181
Abstract
A facile and selective synthesis of N-substituted 2-aminopyridines is accomplished via microwave-assisted multi-component reactions controlled by the basicity of amine and the nature of solvent. In addition, a possible mechanism accounting for the reaction was proposed.
摘要
通过微波辅助多组分反应，利用胺的碱性和溶剂的性质进行控制，实现了N-取代2-氨基吡啶的简便、选择性合成。此外，还提出了一种可能的反应机理。
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