Microwave-assisted Pd(0)-catalyzed amination of aryl halides on solid support.

In this study, the microwave-assisted Pd(0)-catalyzed coupling of aryl halides to Rink resins is compared to a conventional heating protocol. While yields and purities of the coupling products were comparable under both conditions, microwave heating allows a significant acceleration of the reaction. The coupling of electron-deficient aryl halides proceeded within 10-15 minutes, while under conventional conditions 20 h of heating were necessary for complete conversion.