微波辅助固相合成5-羧酰胺基-N-乙酰色胺衍生物
Microwave-assisted solid-phase synthesis of 5-carboxamido-N-acetyltryptamine derivatives.
作者信息
Fînaru Adriana, Berthault Aurélie, Besson Thierry, Guillaumet Gérald, Berteina-Raboin Sabine
机构信息
Institut de Chimie Organique et Analytique, UMR-CNRS 6005, Université d'Orléans, rue de Chartres, BP 6759, France.
出版信息
Org Lett. 2002 Aug 8;4(16):2613-5. doi: 10.1021/ol0259185.
PMID:12153191
Abstract
[reaction: see text] The synthesis of the indole skeleton of new melatoninergic analogues was realized using solid-phase methodology in association with microwave irradiation. This combination speeds up the solid-phase drug discovery process in rigorously established conditions.
摘要
[反应：见正文] 新型褪黑素能类似物吲哚骨架的合成是采用固相方法并结合微波辐射实现的。这种结合在严格设定的条件下加快了固相药物发现过程。
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