Nerem Robert M, Ensley Ann E
Georgia Tech/Emory Center for the Engineering of Living Tissues, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Am J Transplant. 2004;4 Suppl 6:36-42. doi: 10.1111/j.1600-6135.2004.0343.x.
The engineering of biological substitutes and strategies for the replacement and/or repair of blood vessels and the components of the heart represents an important challenge for tissue engineering. In this review, the progress to date and the barriers remaining are addressed. Even though the progress has been considerable and there are even some approaches that have entered clinical trials, we are still a ways off from having FDA-approved replacements and/or repair strategies.
生物替代品的工程设计以及血管和心脏组件的替换和/或修复策略是组织工程面临的一项重大挑战。在本综述中，阐述了迄今为止取得的进展以及尚存的障碍。尽管进展显著，甚至有些方法已进入临床试验阶段，但距离获得美国食品药品监督管理局（FDA）批准的替换和/或修复策略，我们仍有很长的路要走。
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