Priya S Geetha, Jungvid Hans, Kumar Ashok
Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, India.
Tissue Eng Part B Rev. 2008 Mar;14(1):105-18. doi: 10.1089/teb.2007.0318.
Tissue-engineered skin is a significant advance in the field of wound healing. It has mainly been developed because of limitations associated with the use of autografts and allografts where the donor site suffers from pain, infection, and scarring. Recently, tissue-engineered skin replacements have been finding widespread application, especially in the case of burns, where the major limiting factor is the availability of autologous skin. The development of a bioartificial skin facilitates the treatment of patients with deep burns and various skin-related disorders. The present review gives a comprehensive overview of the developments and future prospects of scaffolds as skin substitutes for tissue repair and regeneration.
组织工程皮肤是伤口愈合领域的一项重大进展。它的主要发展是由于自体移植和异体移植存在局限性，供体部位会出现疼痛、感染和瘢痕形成等问题。近年来，组织工程皮肤替代物得到了广泛应用，尤其是在烧伤治疗中，主要限制因素是自体皮肤的可获得性。生物人工皮肤的发展促进了深度烧伤患者和各种皮肤相关疾病的治疗。本综述全面概述了作为组织修复和再生皮肤替代物的支架的发展及未来前景。
