Department of Surgery, Emory University, Atlanta, GA 30332, USA.
Regen Med. 2010 Jan;5(1):107-20. doi: 10.2217/rme.09.77.
Cardiovascular disease is the leading cause of mortality in the USA. The limited availability of healthy autologous vessels for bypass grafting procedures has led to the fabrication of prosthetic vascular conduits. While synthetic polymers have been extensively studied as substitutes in vascular engineering, they fall short of meeting the biological challenges at the blood-material interface. Various tissue engineering strategies have emerged to address these flaws and increase long-term patency of vascular grafts. Vascular cell seeding of scaffolds and the design of bioactive polymers for in situ arterial regeneration have yielded promising results. This article describes the advances made in biomaterials design to generate suitable materials that not only match the mechanical properties of native vasculature, but also promote cell growth, facilitate extracellular matrix production and inhibit thrombogenicity.
心血管疾病是美国的主要死亡原因。用于旁路移植手术的健康自体血管的供应有限，这导致了人造血管移植物的出现。虽然合成聚合物已被广泛研究作为血管工程中的替代品，但它们在应对血液与材料界面的生物学挑战方面仍有不足。各种组织工程策略已经出现，以解决这些缺陷并提高血管移植物的长期通畅率。支架的血管细胞种植和用于原位动脉再生的生物活性聚合物的设计已经取得了有希望的结果。本文描述了在生物材料设计方面的进展，以生成不仅匹配天然血管的机械性能，而且还促进细胞生长、促进细胞外基质产生和抑制血栓形成的合适材料。
