Zhao Jing Hua
Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
Bioinformatics. 2004 May 22;20(8):1325-6. doi: 10.1093/bioinformatics/bth071. Epub 2004 Feb 10.
Computer programs are introduced which calculate pair-wise linkage disequilibrium statistics and conduct haplotype frequency estimation, including X chromosome data, and using a heuristic algorithm to handle multiple genetic markers and missing data.
Programs 2LD, GENECOUNTING and HAP are available on Internet from http://www.hgmp.mrc.ac.uk/~jzhao and http://www.iop.kcl.ac.uk/IoP/Departments/PsychMed/GEpiBSt/software.shtml
介绍了计算机程序,这些程序可计算成对连锁不平衡统计量并进行单倍型频率估计,包括X染色体数据,且使用启发式算法处理多个遗传标记和缺失数据。
程序2LD、GENECOUNTING和HAP可从互联网上的http://www.hgmp.mrc.ac.uk/~jzhao和http://www.iop.kcl.ac.uk/IoP/Departments/PsychMed/GEpiBSt/software.shtml获取。