LdCompare：单标记和多标记r2及遗传覆盖率的快速计算
LdCompare: rapid computation of single- and multiple-marker r2 and genetic coverage.
作者信息
Hao K, Di X, Cawley S
机构信息
Algorithm and Data Analysis, Affymetrix Inc. 3420 Central Expressway, Santa Clara, California, USA.
出版信息
Bioinformatics. 2007 Jan 15;23(2):252-4. doi: 10.1093/bioinformatics/btl574. Epub 2006 Dec 5.
UNLABELLED
The scale of genetic-variation datasets has increased enormously and the linkage equilibrium (LD) structure of these polymorphisms, particularly in whole-genome association studies, is of great interest. The significant computational complexity of calculating single- and multiple-marker correlations at a genome-wide scale remains challenging. We have developed a program that efficiently characterizes whole-genome LD structure on large number of SNPs in terms of single- and multiple-marker correlations.
AVAILABILITY
LdCompare is licensed under the GNU General Public License (GPL). Source code, documentation, testing datasets and precompiled executables are available for download at: http://www.affymetrix.com/support/developer/tools/devnettools.affx
未标注
遗传变异数据集的规模已大幅增加，这些多态性的连锁不平衡（LD）结构，特别是在全基因组关联研究中，备受关注。在全基因组规模上计算单标记和多标记相关性的显著计算复杂性仍然具有挑战性。我们开发了一个程序，该程序可根据单标记和多标记相关性有效地表征大量单核苷酸多态性（SNP）的全基因组LD结构。
可用性
LdCompare根据GNU通用公共许可证（GPL）授权。源代码、文档、测试数据集和预编译的可执行文件可从以下网址下载：http://www.affymetrix.com/support/developer/tools/devnettools.affx
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