Nesbitt Shawna, Victor Ronald G
Internal Medicine/Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Congest Heart Fail. 2004 Jan-Feb;10(1):24-9. doi: 10.1111/j.1527-5299.2004.02021.x.
Hypertension is a compelling disease process that disproportionately affects African Americans. It is the single largest risk factor for cardiovascular disease in African Americans. The end organ manifestations of hypertension are striking and include higher rates of stroke, significantly increased renal disease including end-stage renal disease requiring dialysis, higher risk of left ventricular hypertrophy, and an associated higher risk of heart failure. The cause of these more aggressive end organ phenomena is likely multifactorial and includes a mix of genetic and environmental influences. Intriguing polymorphisms of the epithelial sodium channel are consistent with patterns of hypertension seen in African Americans. Obesity, especially in African-American women, may be closely related to hypertension as a result of sympathetic nervous system stimulation.
高血压是一种极具影响力的疾病进程，对非裔美国人的影响尤为严重。它是非裔美国人患心血管疾病的最大单一风险因素。高血压的终末器官表现显著，包括中风发生率更高、肾病（包括需要透析的终末期肾病）显著增加、左心室肥厚风险更高以及心力衰竭相关风险更高。这些更具侵袭性的终末器官现象的原因可能是多因素的，包括遗传和环境影响的综合作用。上皮钠通道有趣的多态性与非裔美国人中观察到的高血压模式一致。肥胖，尤其是非裔美国女性的肥胖，可能由于交感神经系统刺激而与高血压密切相关。
