Sherman Gayle G, Stevens Gwynneth, Stevens Wendy S
Department of Molecular Medicine and Haematology, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.
Pediatr Infect Dis J. 2004 Feb;23(2):173-6. doi: 10.1097/01.inf.0000109332.83246.1a.
The expense of PCR testing limits diagnosis of HIV infection in infancy in low resource settings. The ultrasensitive p24 antigen assay has been proposed as an accurate substitute; however, its ability to detect different HIV viral subtypes remains to be determined. A sensitivity of 98.1% and specificity of 98.7% was obtained testing 203 samples from 24 HIV-infected and 66 uninfected infants born to HIV subtype C-infected women.
在资源匮乏地区，聚合酶链反应（PCR）检测的费用限制了婴儿期艾滋病毒感染的诊断。超灵敏p24抗原检测法已被提议作为一种准确的替代方法；然而，其检测不同艾滋病毒病毒亚型的能力仍有待确定。对24名感染艾滋病毒的妇女所生的24名感染艾滋病毒婴儿和66名未感染婴儿的203份样本进行检测，获得了98.1%的灵敏度和98.7%的特异性。
