接触1,2,4-三甲基苯的工人尿中3,4-二甲基马尿酸的排泄情况。

Urinary excretion of 3,4-dimethylhippuric acid in workers exposed to 1,2,4-trimethylbenzene.

作者信息

Ichiba M, Hama H, Yukitake S, Kubota M, Kawasaki S, Tomokuni K

机构信息

Department of Community Health Science, Saga Medical School, Japan.

出版信息

Int Arch Occup Environ Health. 1992;64(5):325-7. doi: 10.1007/BF00379541.

DOI:10.1007/BF00379541

PMID:1487328

Abstract

The urinary excretion of 3,4-dimethylhippuric acid (34DMHA), a 1,2,4-trimethylbenzene (124TMB) metabolite, was investigated in workers exposed to 124TMB vapor. The time-weighted average of exposure to 124TMB was determined with a diffusive sampler. For biological monitoring of exposure, urine samples were collected from individual workers and analyzed for metabolites by high-pressure liquid chromatography. The concentration of urinary 34DMHA had a positive correlation with the level of exposure to 124TMB (r = 0.72). The data suggest that 34DMHA is one of the useful indicators for biological monitoring of 124TMB exposure.

摘要

对暴露于1,2,4-三甲基苯（124TMB）蒸气的工人，研究了其1,2,4-三甲基苯代谢物3,4-二甲基马尿酸（34DMHA）的尿排泄情况。使用扩散采样器测定了工人接触124TMB的时间加权平均值。为进行暴露的生物监测，从个体工人处收集尿样，并通过高压液相色谱法分析代谢物。尿中34DMHA的浓度与124TMB的暴露水平呈正相关（r = 0.72）。数据表明，34DMHA是124TMB暴露生物监测的有用指标之一。