测定3,4-二甲基马尿酸作为移印工人三甲基苯暴露的生物监测指标。

Determination of 3,4-dimethylhippuric acid as a biological monitoring index for trimethylbenzene exposure in transfer printing workers.

作者信息

Fukaya Y, Saito I, Matsumoto T, Takeuchi Y, Tokudome S

机构信息

Department of Public Health, Nagoya City University Medical School, Japan.

出版信息

Int Arch Occup Environ Health. 1994;65(5):295-7. doi: 10.1007/BF00405692.

DOI:10.1007/BF00405692

PMID:8175183

Abstract

The relationship between exposure to 1,2,4-trimethylbenzene (1,2,4-TMB) and urinary concentration of 3,4-dimethylhippuric acid (3,4-DMHA), one of its metabolites, was studied in workers involved in transfer printing. Airborne TMBs were sampled by an organic vapor monitoring badge and analyzed by capillary gas chromatography. Urinary 3,4-DMHA and creatinine were analyzed under the same conditions of high-performance liquid chromatography. The exposure concentration of 1,2,4-TMB among workers was around 25 ppm, the threshold limit value (TLV). The urinary concentration of 3,4-DMHA was low at the start of each shift and high at the end. Exposure to the TLV (25 ppm) of 1,2,4-TMB results in a urinary 3,4-DMHA concentration of 410 mg/g creatinine (r = 0.897, P < 0.001). Urinary 3,4-DMHA concentration could be used as a biological monitoring index for 1,2,4-TMB exposure.

摘要

在从事移印工作的工人中，研究了接触1,2,4-三甲基苯（1,2,4-TMB）与其代谢产物之一3,4-二甲基马尿酸（3,4-DMHA）尿浓度之间的关系。通过有机蒸气监测徽章对空气中的TMB进行采样，并采用毛细管气相色谱法进行分析。在相同的高效液相色谱条件下分析尿中的3,4-DMHA和肌酐。工人中1,2,4-TMB的接触浓度约为25 ppm，即阈限值（TLV）。每班开始时尿中3,4-DMHA浓度较低，而结束时较高。接触1,2,4-TMB的TLV（25 ppm）会导致尿中3,4-DMHA浓度达到410 mg/g肌酐（r = 0.897，P < 0.001）。尿中3,4-DMHA浓度可作为1,2,4-TMB接触的生物监测指标。