多巴胺对正常人和外源性哮喘患者气道传导率的影响。
Effect of dopamine on airways conductance in normals and extrinsic asthmatics.
作者信息
Thomson N C, Patel K R
出版信息
Br J Clin Pharmacol. 1978 May;5(5):421-4. doi: 10.1111/j.1365-2125.1978.tb01648.x.
Abstract
1 Specific conductance was measured before and after infused and/or inhaled dopamine in nine normal subjects and twelve patients with extrinsic bronchial asthma. 2 There was no significant change in conductance in either group. 3 The alpha-adrenergic receptor antagonist thymoxamine infused in combination with dopamine had no significant effect on conductance in three asthmatics. 4 It is concluded that dopamine has no acute effect on airways resistance and that specific dopamine receptors are unlikely to exist in human airways.
摘要
- 在9名正常受试者和12名外源性支气管哮喘患者中，在输注和/或吸入多巴胺前后测量了比电导。2. 两组的电导均无显著变化。3. 与多巴胺联合输注的α-肾上腺素能受体拮抗剂百里胺对3名哮喘患者的电导无显著影响。4. 得出的结论是，多巴胺对气道阻力无急性影响，且人气道中不太可能存在特异性多巴胺受体。
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