Ro 23-9424对嗜肺军团菌临床分离株的体外活性。
In vitro activity of Ro 23-9424 against clinical isolates of Legionella species.
作者信息
Edelstein P H, Edelstein M A
机构信息
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
出版信息
Antimicrob Agents Chemother. 1992 Nov;36(11):2559-61. doi: 10.1128/AAC.36.11.2559.
Abstract
Agar and broth microdilution MICs of Ro 23-9424 that inhibited 90% of 22 Legionella clinical isolates tested were 0.64 and 0.08 micrograms/ml, respectively; respective erythromycin values were 1.0 and 0.12 micrograms/ml. Ro 23-9424 (1 microgram/ml) was slightly more active than the same erythromycin concentration in a macrophage system, for both Legionella pneumophila strains studied.
摘要
对22株嗜肺军团菌临床分离株中90%有抑制作用的Ro 23 - 9424在琼脂和肉汤微量稀释法中的最低抑菌浓度（MIC）分别为0.64和0.08微克/毫升；红霉素的相应值分别为1.0和0.12微克/毫升。在所研究的两株嗜肺军团菌菌株中，在巨噬细胞系统中，Ro 23 - 9424（1微克/毫升）比相同浓度的红霉素活性略高。
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