青春期生长激素缺乏会降低成人骨矿物质密度。
Growth hormone deficiency during puberty reduces adult bone mineral density.
作者信息
Hyer S L, Rodin D A, Tobias J H, Leiper A, Nussey S S
机构信息
Department of Biochemical Medicine, St George's Hospital Medical School, London.
出版信息
Arch Dis Child. 1992 Dec;67(12):1472-4. doi: 10.1136/adc.67.12.1472.
Abstract
Bone mineral density (BMD) was evaluated by dual energy x ray absorptiometry in 60 adults (33 males, 27 females; aged 50, range 23-76 years) who were growth hormone deficient from various causes for 10.4 (1-31) years. Adult patients who had acquired growth hormone deficiency before completion of puberty had significantly reduced mean (SEM) BMD compared with age matched healthy controls at the lumbar spine: 0.87 (0.09) v 1.20 (0.03) g/cm2, femoral neck: 0.81 (0.06) v 1.08 (0.04) g/cm2, and Ward's triangle: 0.68 (0.07) v 1.04 (0.05) g/cm2. These values were also reduced compared with those of patients who had received human growth hormone during puberty. Untreated growth hormone deficiency when present during puberty results in reduced adult bone density.
摘要
采用双能X线吸收法对60名成年人（33名男性，27名女性；年龄50岁，范围23 - 76岁）的骨矿物质密度（BMD）进行评估，这些成年人因各种原因生长激素缺乏达10.4（1 - 31）年。青春期结束前获得性生长激素缺乏的成年患者，与年龄匹配的健康对照相比，腰椎的平均（标准误）骨密度显著降低：分别为0.87（0.09）vs 1.20（0.03）g/cm²、股骨颈：0.81（0.06）vs 1.08（0.04）g/cm²、沃德三角区：0.68（0.07）vs 1.04（0.05）g/cm²。与青春期期间接受过人生长激素治疗的患者相比，这些数值也降低了。青春期时存在的未治疗的生长激素缺乏会导致成年后骨密度降低。
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