小鼠派尔集合淋巴结滤泡相关M细胞摄取荧光珠的共聚焦分析。

Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associated M cells.

作者信息

Porta C, James P S, Phillips A D, Savidge T C, Smith M W, Cremaschi D

机构信息

Dipartimento di Fisiologia e Biochimica Generali, Universita degli Studi di Milano, Italy.

出版信息

Exp Physiol. 1992 Nov;77(6):929-32. doi: 10.1113/expphysiol.1992.sp003662.

DOI:10.1113/expphysiol.1992.sp003662

PMID:1489550

Abstract

Latex beads coated with secretory immunoglobulin (IgA) instilled into mouse intestinal loops are taken up by M cells present in Peyer's patch follicle-associated epithelial tissue. Bead adsorption and uptake is greater at the edge compared with the apex of follicle domes. Coating beads with bovine serum albumin (BSA) causes a fourfold reduction in adsorption and a twentyfold reduction in uptake. Results demonstrate selectivity between adsorption and uptake and between the ability of different proteins to facilitate uptake.

摘要

将包被有分泌型免疫球蛋白（IgA）的乳胶珠注入小鼠肠袢后，派尔集合淋巴结滤泡相关上皮组织中的M细胞会摄取这些乳胶珠。与滤泡穹顶顶端相比，边缘处的珠子吸附和摄取量更大。用牛血清白蛋白（BSA）包被珠子会使吸附量降低四倍，摄取量降低二十倍。结果表明，在吸附和摄取之间以及不同蛋白质促进摄取的能力之间存在选择性。