Keiser P, Keay S, Wasserman S, Wecksler W
Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201.
AIDS Res Hum Retroviruses. 1992 Nov;8(11):1919-27. doi: 10.1089/aid.1992.8.1919.
We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies were found 90 to 540 days before antibodies to HIV-1 were detectable. In comparison, anti-CD4 antibodies were present in only 7 serum samples from 62 HIV-1 seronegative individuals, including 50 from a seronegative homosexual male cohort. These results suggest that anti-CD4 antibodies are generated in response to early HIV-1 infection and possibly could be used as a marker for HIV-1 infection in some infected persons who are seronegative for HIV-1.
我们检测了14名HIV-1血清转化者的血清中是否存在抗CD4自身抗体。在13名HIV-1感染者血清转化时，有11人的血清中检测到了抗CD4抗体。在14名于HIV-1血清转化前采集血清的人中，有6人在可检测到HIV-1抗体之前90至540天就发现了抗CD4抗体。相比之下，在62名HIV-1血清阴性个体的7份血清样本中发现了抗CD4抗体，其中包括50份来自血清阴性同性恋男性队列的样本。这些结果表明，抗CD4抗体是对早期HIV-1感染的反应而产生的，并且在一些HIV-1血清阴性的感染者中可能可用作HIV-1感染的标志物。
