喹乙醇体外光毒性的验证
Demonstration of olaquindox phototoxicity in vitro.
作者信息
Eberlein B, Bergner T, Przybilla B
机构信息
Dermatology Clinic, Ludwig-Maximilian University, Munich, Germany.
出版信息
Photodermatol Photoimmunol Photomed. 1992 Apr;9(2):63-6.
Olaquindox is an oral anti-bacterial agent used as an additive to animal food. It is known to cause photosensitization in pig breeders, probably due to a photoallergic mechanism. Also, olaquindox was found to be phototoxic in animal experiments. We have evaluated the phototoxic properties of olaquindox in vitro with a photohemolysis test using different light sources. Irradiation with a source rich in ultraviolet A (UVA) and, to a lesser degree, with a lamp emitting mainly visible light induced photohemolysis, which depended on the concentration of olaquindox and the radiation dose. Exposure to radiation rich in UVB caused no olaquindox-dependent hemolysis. The absorption spectrum of olaquindox changed prominently after irradiation, indicating photodegradation of the compound.
喹乙醇是一种用作动物饲料添加剂的口服抗菌剂。已知它会使养猪者产生光敏反应，这可能是由于光过敏机制所致。此外，在动物实验中发现喹乙醇具有光毒性。我们使用不同光源通过光溶血试验在体外评估了喹乙醇的光毒性特性。富含紫外线A（UVA）的光源照射以及程度较轻的主要发射可见光的灯照射会诱导光溶血，这取决于喹乙醇的浓度和辐射剂量。暴露于富含UVB的辐射下不会引起喹乙醇依赖性溶血。喹乙醇的吸收光谱在照射后发生了显著变化，表明该化合物发生了光降解。
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