来自树状枝顶孢霉的肺炎念珠菌素。III. 结构解析。

Pneumocandins from Zalerion arboricola. III. Structure elucidation.

作者信息

Hensens O D, Liesch J M, Zink D L, Smith J L, Wichmann C F, Schwartz R E

机构信息

Department of Natural Products Chemistry, Merck Research Laboratories, Rahway, N.J. 07065-0900.

出版信息

J Antibiot (Tokyo). 1992 Dec;45(12):1875-85. doi: 10.7164/antibiotics.45.1875.

DOI:10.7164/antibiotics.45.1875

PMID:1490878

Abstract

Pneumocandin B0 (6) and six related lipopeptides are antifungal and anti-Pneumocystis carinii agents from mutants of Zalerion arboricola, whose structures were determined mainly on the basis of spectroscopic analysis. They belong, along with pneumocandin A0 (L-671,329) previously isolated from these laboratories, to the echinocandin class of antifungal agents. The product from base-catalyzed ring opening involving the hemiaminal position of the dihydroxyornithine residue of B0, has been clearly defined as 6b. Modifications were limited to the 3-hydroxy-4-methylproline, 3,4-dihydroxyhomotyrosine and 4,5-dihydroxyornithine residues of pneumocandin A0.

摘要

喷他康唑B0（6）和六种相关脂肽是从树状枝孢霉突变体中提取的抗真菌和抗卡氏肺孢子虫药物，其结构主要通过光谱分析确定。它们与先前从这些实验室分离出的喷他康唑A0（L-671,329）一起，属于棘白菌素类抗真菌剂。涉及B0中二羟基鸟氨酸残基半缩醛胺位置的碱催化开环产物已明确确定为6b。修饰仅限于喷他康唑A0的3-羟基-4-甲基脯氨酸、3,4-二羟基高酪氨酸和4,5-二羟基鸟氨酸残基。