来自树状枝孢霉的肺炎链菌素。I. 发现与分离

Pneumocandins from Zalerion arboricola. I. Discovery and isolation.

作者信息

Schwartz R E, Sesin D F, Joshua H, Wilson K E, Kempf A J, Goklen K A, Kuehner D, Gailliot P, Gleason C, White R

机构信息

Merck Research Laboratories, Rahway, N.J. 07065-0900.

出版信息

J Antibiot (Tokyo). 1992 Dec;45(12):1853-66. doi: 10.7164/antibiotics.45.1853.

DOI:10.7164/antibiotics.45.1853

PMID:1490876

Abstract

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneumocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.

摘要

对树状枝孢菌定向生物合成进行的高效液相色谱生物自显影，促成了抗真菌和抗卡氏肺孢子虫脂肽新药——喷他脒菌素B0（L-688,786）的发现。已开发出分离技术，用于在树状枝孢菌突变体发酵过程中，将该成分与喷他脒菌素A0（L-671,329）分离。还分离出了许多相关化合物，它们在鸟氨酸、高酪氨酸和脯氨酸的羟基化模式上与喷他脒菌素A0和B0不同。