喷他康唑D0，一种新型抗真菌剂，也是卡氏肺孢子虫的强效抑制剂。
Pneumocandin D0, a new antifungal agent and potent inhibitor of Pneumocystis carinii.
作者信息
Morris S A, Schwartz R E, Sesin D F, Masurekar P, Hallada T C, Schmatz D M, Bartizal K, Hensens O D, Zink D L
机构信息
Merck Research Laboratories, Rahway, NJ 07065-0900.
出版信息
J Antibiot (Tokyo). 1994 Jul;47(7):755-64. doi: 10.7164/antibiotics.47.755.
Pneumocandin D0 (9), a new member of the echinocandin class of antifungal agents, has been isolated as a minor constituent from fermentation broths of the filamentous fungi Zalerion arboricola (ATCC 20957). The structure of 9 has been determined mainly on the basis of spectroscopic analysis and by comparison with published data for similar compounds. To date, pneumocandin D0 has been found to be the most potent inhibitor of Pneumocystis carinii development in vivo within the natural-occurring echinocandin family of antifungal agents.
棘白菌素类抗真菌剂的新成员——肺炎念珠菌素D0（9），已从丝状真菌树状枝孢菌（ATCC 20957）的发酵液中作为次要成分分离出来。9的结构主要通过光谱分析并与类似化合物的已发表数据进行比较来确定。迄今为止，在天然存在的棘白菌素类抗真菌剂家族中，肺炎念珠菌素D0已被发现是体内对卡氏肺孢子虫发育最有效的抑制剂。
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