指状环素，由一种指孢囊菌属菌株产生的新型四环素衍生物。I. 分类学、生产、分离及生物活性。

Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity.

作者信息

Wells J S, O'Sullivan J, Aklonis C, Ax H A, Tymiak A A, Kirsch D R, Trejo W H, Principe P

机构信息

Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000.

出版信息

J Antibiot (Tokyo). 1992 Dec;45(12):1892-8. doi: 10.7164/antibiotics.45.1892.

DOI:10.7164/antibiotics.45.1892

PMID:1490880

Abstract

A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline.

摘要

对具有抗四环素抗性微生物活性的抗生素进行筛选，已分离出指孢囊菌属菌株（ATCC 53693），它是几种新型四环素衍生物的产生菌。主要发酵产物指环素A和指环素B被纯化，并测定了其对四环素抗性和四环素敏感革兰氏阳性菌的最低抑菌浓度（MIC）值。指环素是首个天然存在的四环素C2酰胺，与四环素无交叉抗性。