Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. III. Absolute stereochemistry of the dactylocyclines.
作者信息
Devasthale P V, Mitscher L A, Telikepalli H, Vander Velde D, Zou J Y, Ax H A, Tymiak A A
机构信息
Department of Medicinal Chemistry, University of Kansas, Lawrence 66045-2506.
出版信息
J Antibiot (Tokyo). 1992 Dec;45(12):1907-13. doi: 10.7164/antibiotics.45.1907.
PMID:1490882
Abstract
The dactylocycline antibiotics were found through circular dichroism measurements, NMR spectroscopy and chemical transformations to possess the usual tetracycline family absolute configuration at carbons 4, 4a, 5a and 12a. The absolute stereochemistry about the C-6 carbon, however, was the reverse of that found with previously investigated tetracyclines.
摘要
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