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α-糖硫己醚，由“塞贝基亚”属LL-14E605菌株产生的一种新型抗生素。II. 分离及理化性质表征

Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. II. Isolation and physical-chemical characterization.

作者信息

Northcote P T, Williams D, Manning J K, Borders D B, Maiese W M, Lee M D

机构信息

Natural Products Research Section, American Cyanamid Company, Pearl River, New York 10965.

出版信息

J Antibiot (Tokyo). 1994 Aug;47(8):894-900. doi: 10.7164/antibiotics.47.894.

DOI:10.7164/antibiotics.47.894
PMID:7928676
Abstract

Glycothiohexide alpha was recovered from the fermentation broth of a "Sebekia" sp. by mixed solvent extraction, selective precipitation and adsorption chromatography on Diaion HP-20. The amount of glycothiohexide alpha present in the crude preparation was enriched by photolysis. Purification of glycothiohexide alpha was accomplished by repetitive countercurrent chromatography.

摘要

通过混合溶剂萃取、选择性沉淀以及在Diaion HP - 20上进行吸附色谱法，从一种“Sebekia”属菌株的发酵液中回收了α-糖硫己醚。粗制品中存在的α-糖硫己醚的量通过光解得以富集。α-糖硫己醚的纯化通过重复逆流色谱法完成。

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