Radermacher P, Falke K J, Park Y S, Ahn D W, Hong S K, Qvist J, Zapol W M
Zentrum für Anaesthesiologie, Heinrich-Heine-Universität, Düsseldorf, Federal Republic of Germany.
J Appl Physiol (1985). 1992 Dec;73(6):2592-5. doi: 10.1152/jappl.1992.73.6.2592.
Intravascular bubble formation and symptoms of decompression sickness have been reported during repetitive deep breath-hold diving. Therefore we examined the pattern of blood N2 kinetics during and after repetitive breath-hold diving. To study muscle N2 uptake and release, we measured brachial venous N2 partial pressure (PN2) in nine professional Korean breath-hold divers (ama) during a 3-h diving shift at approximately 4 m seawater depth and up to 4 h after diving. PN2 was determined with the manometric Van Slyke method. Diving time and depth were recorded using a backpack computer-assisted dive longer that allowed calculating the surface-to-depth time ratio to derive the effective depth. With the assumption that forearm muscle N2 kinetics follow the general Haldanian principles of compression and decompression, i.e., forearm muscle is a single compartment with a uniform tissue PN2 equal to venous PN2, PN2 data were fitted to monoexponential functions of time. In the early phase of the diving shift, PN2 rapidly increased to 640 Torr (half time = 6 min) and then slowly declined to baseline levels (half time = 36 min) after the work shift. Peak PN2 levels approximated the alveolar PN2 derived from the effective depth. We conclude that forearm muscle N2 kinetics are well described by a Haldanian single-compartment model. Decompression sickness is theoretically possible in the ama; it did not occur because the absolute PN2 remained low due to the shallow working depth of the ama we studied.
据报道，在重复屏气潜水过程中会出现血管内气泡形成和减压病症状。因此，我们研究了重复屏气潜水期间及之后血液中氮气动力学模式。为了研究肌肉对氮气的摄取和释放，我们在9名韩国专业屏气潜水员（阿马）于约4米海水深度进行3小时潜水作业期间以及潜水后长达4小时内，测量了肱静脉氮气分压（PN2）。PN2采用压力测定范斯莱克法测定。潜水时间和深度通过背包式计算机辅助潜水记录器记录，该记录器能够计算从水面到深度的时间比以得出有效深度。假设前臂肌肉的氮气动力学遵循一般的哈代压缩和减压原理，即前臂肌肉是一个单一隔室，其组织PN2均匀且等于静脉PN2，将PN2数据拟合为时间的单指数函数。在潜水作业的早期阶段，PN2迅速升至640托（半衰期 = 6分钟），然后在作业结束后缓慢降至基线水平（半衰期 = 36分钟）。PN2峰值水平接近根据有效深度得出的肺泡PN2。我们得出结论，哈代单隔室模型能够很好地描述前臂肌肉的氮气动力学。理论上阿马潜水员有可能患减压病；但在我们研究的阿马潜水员中未发生减压病，因为由于作业深度较浅，绝对PN2一直较低。
