Mazziotti F, Cirillo L, Arena V, Cipriani P, Ghezzi C, Bresadola M, Ragni N, Donadio C, Pellizzari G
II Clinica di Ostetricia e Ginecologia, Università La Sapienza di Roma.
Minerva Ginecol. 1992 Dec;44(12):653-9.
A multicentre trial was carried out in Italy with the aim of comparing the efficacy, safety and tolerability of the oral administration of fluconazole with the oral administration of ketoconazole in the treatment of patients affected by Candida vulvovaginitis. A total of 174 patients with symptomatic Candida vulvovaginitis were identified both by objective examination and cell culture tests: of these 87 were treated using a single oral administration of fluconazole (150 mg) whereas the other 87 received 2 200 mg capsules of ketoconazole daily for 5 days. Tests to assess the efficacy, safety and tolerability of both treatments were carried out approximately 7 days and 5-6 weeks from the start of therapy. The results obtained showed a success rate of 92% for fluconazole-treated patients and 83% for those treated with ketoconazole. In addition to the rapid and safe efficacy of treatment, the most important findings which emerged from this study were the extreme simplicity of use, excellent patient compliance and the complete absence of collateral effects of variations in the hematochemical and urine parameters taken into consideration caused by fluconazole.
在意大利进行了一项多中心试验，目的是比较口服氟康唑与口服酮康唑治疗念珠菌性外阴阴道炎患者的疗效、安全性和耐受性。通过客观检查和细胞培养测试共确定了174例有症状的念珠菌性外阴阴道炎患者：其中87例接受单次口服氟康唑（150毫克）治疗，而另外87例每天服用2粒200毫克酮康唑胶囊，持续5天。在治疗开始后约7天和5至6周进行了评估两种治疗方法的疗效、安全性和耐受性的测试。获得的结果显示，氟康唑治疗的患者成功率为92%，酮康唑治疗的患者成功率为83%。除了治疗的快速和安全疗效外，这项研究中出现的最重要发现是使用极其简单、患者依从性极佳，以及氟康唑引起的所考虑的血液化学和尿液参数变化完全没有副作用。
