Ichise M, Salit I E, Abbey S E, Chung D G, Gray B, Kirsh J C, Freedman M
Department of Radiology (Division of Nuclear Medicine), University of Toronto, Canada.
Nucl Med Commun. 1992 Oct;13(10):767-72.
Chronic fatigue syndrome (CFS) is a severely disabling illness of uncertain aetiology. It is characterized by a chronic, sustained or fluctuating sense of debilitating fatigue without any other known underlying medical conditions. It is also associated with both somatic and neuropsychological symptoms. Both physical and laboratory findings are usually unremarkable. Regional cerebral blood flow (rCBF) was assessed in 60 clinically defined CFS patients and 14 normal control (NC) subjects using 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) single photon emission computed tomography (SPECT). Compared with the NC group, the CFS group showed significantly lower cortical/cerebellar rCBF ratios, throughout multiple brain regions (P < 0.05). Forty-eight CFS subjects (80%) showed at least one or more rCBF ratios significantly less than normal values. The major cerebral regions involved were frontal (38 cases, 63%), temporal (21 cases, 35%), parietal (32 cases, 53%) and occipital lobes (23 cases, 38%). The rCBF ratios of basal ganglia (24 cases, 40%) were also reduced. 99Tcm-HMPAO brain SPECT provided objective evidence for functional impairment of the brain in the majority of the CFS subjects. The findings may not be diagnostic of CFS but 99Tcm-HMPAO SPECT may play an important role in clarifying the pathoaetiology of CFS. Further studies are warranted.
慢性疲劳综合征（CFS）是一种病因不明的严重致残性疾病。其特征为慢性、持续或波动的使人衰弱的疲劳感，且无任何其他已知的潜在疾病。它还伴有躯体和神经心理症状。体格检查和实验室检查结果通常无异常。使用99锝-六甲基丙烯胺肟（99Tcm-HMPAO）单光子发射计算机断层扫描（SPECT）对60例临床确诊的CFS患者和14名正常对照（NC）受试者进行了局部脑血流（rCBF）评估。与NC组相比，CFS组在多个脑区的皮质/小脑rCBF比值显著降低（P < 0.05）。48例CFS受试者（80%）显示至少有一个或多个rCBF比值明显低于正常值。主要受累脑区为额叶（38例，63%）、颞叶（21例，35%）、顶叶（32例，53%）和枕叶（23例，38%）。基底节的rCBF比值（24例，40%）也降低。99Tcm-HMPAO脑SPECT为大多数CFS受试者的脑功能损害提供了客观证据。这些发现可能无法诊断CFS，但99Tcm-HMPAO SPECT可能在阐明CFS的病理病因方面发挥重要作用。有必要进行进一步研究。
