Kao C H, Wang P Y, Wang S J, Chou K T, Hsu C Y, Lin W Y, Liao S Q, Yeh S H
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Nucl Med Commun. 1993 Jan;14(1):47-51. doi: 10.1097/00006231-199301000-00010.
Fourteen young patients with Down's syndrome (nine males, five females, age range 8-30 years) were studied. 99Tcm-hexamethylpropylene amine oxime (HMPAO) brain single photon emission computed tomography (SPECT) was performed to evaluate regional cerebral blood flow (rCBF). Two experienced nuclear medicine physicians analysed the results of the SPECT by visual interpretation. The SPECT in all 14 patients with Down's syndrome invariably showed significantly unilateral perfusion defects in the temporal-parietal-occipital region, occasionally combined with small perfusion defects over other discrete cerebral areas. In this preliminary study, 99Tcm-HMPAO brain SPECT in the patients with Down's syndrome were abnormal. Patterns of rCBF in Down's syndrome were similar to the usual images of rCBF in Alzheimer's disease reported in the literature. Our findings provide new evidence of the similarities between Down's syndrome and Alzheimer's disease.
对14名唐氏综合征年轻患者（9名男性，5名女性，年龄范围8 - 30岁）进行了研究。采用99锝-六甲基丙烯胺肟（HMPAO）脑单光子发射计算机断层扫描（SPECT）来评估局部脑血流量（rCBF）。两名经验丰富的核医学医师通过视觉解读分析了SPECT的结果。所有14名唐氏综合征患者的SPECT均始终显示颞顶枕区存在明显的单侧灌注缺损，偶尔合并其他离散脑区的小灌注缺损。在这项初步研究中，唐氏综合征患者的99锝-HMPAO脑SPECT异常。唐氏综合征的rCBF模式与文献中报道的阿尔茨海默病的rCBF常见图像相似。我们的研究结果为唐氏综合征和阿尔茨海默病之间的相似性提供了新证据。
