Kao C H, Wang S J, Yeh S H
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Nucl Med Commun. 1994 Feb;15(2):94-8. doi: 10.1097/00006231-199402000-00005.
The aim of this study was to describe the effectiveness of 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) brain single photon emission computed tomography (SPECT) in the assessment of the regional cerebral blood flow (rCBF) in amphetamine abusers. Twenty-one amphetamine abusers were included and 99Tcm-HMPAO brain SPECT performed to evaluate rCBF. The drug-using periods ranged from 1 month to several years. The demonstrated neuropsychogenic symptoms and signs of the abusers were from normal presentation to various neurologic complications. The brain SPECT scans were interpreted visually as either normal or abnormal. The degree of abnormality was classified into mild or severe. The results revealed that (a) most SPECT studies in abusers show small defects (95%, 20/21 cases); 71% (15/21) of cases revealed multiple defects over both hemispheres (classified as severe); 24% (5/21) of the cases had focal defects (classified as mild); and only one case (5%, 1/21) demonstrated a normal SPECT finding; (b) the degree of abnormality on SPECT scans was not related to the dose and duration of drug use or the severity of the neuropsychiatric symptoms and signs. In conclusion, 99Tcm-HMPAO brain SPECT is a sensitive but not specific test for neuropsychogenic abnormalities associated with amphetamine abuse.
本研究的目的是描述锝[99Tcm] - 六甲基丙烯胺肟（99Tcm - HMPAO）脑单光子发射计算机断层扫描（SPECT）在评估苯丙胺滥用者局部脑血流量（rCBF）方面的有效性。纳入了21名苯丙胺滥用者，并进行了99Tcm - HMPAO脑SPECT检查以评估rCBF。吸毒时间从1个月到数年不等。滥用者表现出的神经精神症状和体征从正常表现到各种神经系统并发症。脑SPECT扫描经视觉解读为正常或异常。异常程度分为轻度或重度。结果显示：（a）滥用者的大多数SPECT研究显示小的缺损（95%，20/21例）；71%（15/21）的病例在双侧半球出现多个缺损（分类为重度）；24%（5/21）的病例有局灶性缺损（分类为轻度）；只有1例（5%，1/21）SPECT检查结果正常；（b）SPECT扫描的异常程度与吸毒剂量和持续时间或神经精神症状和体征的严重程度无关。总之，99Tcm - HMPAO脑SPECT是检测与苯丙胺滥用相关的神经精神异常的一项敏感但非特异性的检查。
