Alekseeva I A, Kodentsova V M, Vrzhesinskaia O A, Zvereva T E, Khotimchenko S A, Spirichev V B
Vopr Med Khim. 1992 Sep-Oct;38(5):17-20.
Alimentary deficiency in riboflavin and/or iron in rats involved distinct decrease in excretion of 4-pyridoxylic acid and 1-N-methyl nicotinamide--the metabolites considered as the indices of vitamins B6 and PP consumption. The effect observed appears to occur due to a decrease in activity of some iron- and flavin-containing enzymes participating in the metabolism of pyridoxine and niacin. Addition to the diet of the deficient component normalized these patterns. Use of the data on excretion of 4-pyridoxylic acid and 1-N-methyl nicotinamide as criteria of consumption of pyridoxine and niacin is discussed.
大鼠饮食中核黄素和/或铁缺乏会导致4-吡啶氧酸和1-N-甲基烟酰胺排泄量明显减少，这两种代谢产物被视为维生素B6和维生素PP（烟酸）消耗的指标。观察到的这种效应似乎是由于参与吡哆醇和烟酸代谢的一些含铁和黄素的酶的活性降低所致。在缺乏成分的饮食中添加相应成分可使这些模式恢复正常。文中还讨论了将4-吡啶氧酸和1-N-甲基烟酰胺的排泄数据用作吡哆醇和烟酸消耗标准的情况。
