Kodentsova V M, Vrzhesinskaia O A, Spirichev V B
Vopr Med Khim. 1992 Jan-Feb;38(1):22-5.
Alimentary deficiency of riboflavin in rats caused a decrease in excretion of vitamin B2 with urine simultaneously with lowering in daily excretion of 4-pyridoxylic acid (4-PA) and N1-methyl nicotinamide (N1-MNA); these patterns are usually used as indicators of pyridoxine and niacin availability. The similar decrease in excretion of 4-PA and N1-MNA with urine but without alterations in NAD+NADP concentrations in erythrocytes was detected in women deficient in vitamin B2. Content of nicotinamide coenzymes in erythrocytes correlated with excretion of N1-MNA with urine only under normal conditions of riboflavin availability. Use of the criteria involving rates of 4-PA and N1-MNA excretion for evaluation of pyridoxine and niacin deficiency is discussed.
大鼠饮食中核黄素缺乏导致维生素B2尿排泄量减少，同时4-吡哆酸（4-PA）和N1-甲基烟酰胺（N1-MNA）的每日排泄量降低；这些指标通常用于衡量维生素B6和烟酸的可利用性。在维生素B2缺乏的女性中，也检测到4-PA和N1-MNA随尿液排泄量有类似减少，但红细胞中NAD + NADP浓度无变化。仅在核黄素可利用的正常情况下，红细胞中烟酰胺辅酶的含量才与N1-MNA的尿排泄量相关。本文讨论了使用4-PA和N1-MNA排泄率标准来评估维生素B6和烟酸缺乏的情况。
