日本和美国前列腺癌患者的生存率分析

Analysis of survival of prostate cancer patients in Japan and the U.S.A.

作者信息

Imai K, Suzuki T, Shimizu T, Yamanaka H, Kanetake H, Sakai H, Minami Y, Saito Y

机构信息

Gunma University Oncology Study Group, School of Medicine, Gunma University, Maebashi, Japan.

出版信息

Adv Exp Med Biol. 1992;324:29-38. doi: 10.1007/978-1-4615-3398-6_4.

DOI:10.1007/978-1-4615-3398-6_4

PMID:1492623

Abstract

The prognosis of U.S.A. patients with prostate cancer based on reports from the American College of Surgeons and Roswell Park Cancer Institute was compared with that of Japanese in Nagasaki and Gunma. There was more than a 10% difference in survival rate between the two countries. Several clinical parameters were analyzed to determine the basis for this difference. In general, stage distribution, metastatic sites, bone pain and alkaline phosphatase in the USA patients with Stage D disease were more severe than in the Japanese patients. Moreover the prostate cancer death rate in the USA was higher than that in Japan. However, only the distribution of pathological grade in the USA was better than that in Japan. From these results, it is difficult to conclude that prostate cancer in the USA is more aggressive than in Japan. The possibility of selection bias in these studies is discussed.

摘要

根据美国外科医师学会和罗斯韦尔帕克癌症研究所的报告，对美国前列腺癌患者与日本长崎和群马县患者的预后进行了比较。两国之间的生存率差异超过10%。分析了几个临床参数以确定这种差异的依据。总体而言，美国D期疾病患者的分期分布、转移部位、骨痛和碱性磷酸酶比日本患者更为严重。此外，美国前列腺癌死亡率高于日本。然而，只有美国的病理分级分布比日本好。从这些结果来看，很难得出美国前列腺癌比日本更具侵袭性的结论。讨论了这些研究中选择偏倚的可能性。