Nishijima Y, Uchida K, Koiso K, Nemoto R
Department of Urology, University of Tsukuba, Ibaraki, Japan.
Adv Exp Med Biol. 1992;324:93-100. doi: 10.1007/978-1-4615-3398-6_9.
A total of 75 prostate cancer and 67 lung cancer patients with positive bone scintigrams were studied. The patterns of spread in the axial skeleton and pelvis were different between the groups. The differences in the distribution of bony metastases between prostate and lung are explained by the role of Batson's vertebral venous plexus. We developed an animal model of spinal bone metastasis to prove this route. As suspension of tumor cells was injected into the tail vein of mice with vena caval occlusion. This procedure reproducibly resulted in metastatic tumor growth in the lumbar region of the vertebral column. The prevalence of spinal bone metastasis is attributed to passage of tumor cells via the vertebral venous plexus.
共研究了75例骨闪烁扫描呈阳性的前列腺癌患者和67例骨闪烁扫描呈阳性的肺癌患者。两组患者在中轴骨骼和骨盆中的扩散模式不同。前列腺癌和肺癌骨转移分布的差异是由巴特森椎静脉丛的作用来解释的。我们建立了一个脊柱骨转移的动物模型来证明这条转移途径。将肿瘤细胞悬液注入腔静脉闭塞小鼠的尾静脉。该操作可重复性地导致脊柱腰椎区域出现转移性肿瘤生长。脊柱骨转移的发生率归因于肿瘤细胞通过椎静脉丛的转移。
